الفهرس 
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Abstract
Thyroid gland is an endocrine gland situated in the anterior side of the neck. Its main function is regulation of the basal metabolic rate, stimulation of somatic and psychic growth, and plays an important role in calcium metabolism.
Multinodular goiter (MNG) is defined as the palpation of multiple distinct nodules in the enlarged thyroid gland .The etiopathogenesis of MNG is not very clear. A mild dietary deficiency of iodine, slight impairment of hormone synthesis, increased iodide clearance from the kidneys, and the presence of thyroid-stimulating immunoglobulin’s have been suggested as the various causes.
Aim of our study is to Evaluate the sensitivity and specificity of ultrasonography and FNAC in multi-nodular goiter pathology in comparison to surgery.
This study was conducted in Minia university hospital it was prospective study including 90 patients with multi-nodular goiter thorough history and clinical examination. Laboratory evaluation was done for assessing the TSH, free T3 and free T4. For all patients, Ultrasound examination was done to evaluate the Size, Calcification, vascularity, echogenicity, solid or cystic nodule, extension outside capsule and LNs affection
FNAC was also done for all patients .All the patients were managed surgically and diagnosis was confirmed from the histopathological examination reports.
Histopathological diagnosis after thyroidectomy was taken as the gold standard and the FNAC and USS diagnoses were compared to it.
This study showing that USG is 72.43% sensitive and 90.12% specific in detection of malignancy in nodular goitre whereas FNAC is 93% sensitive and 98% specific in the same regard.