الفهرس 
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Abstract
The hydrazones and their transition metal complexes have been well documented in the literature as good antimicrobial, anticonvulsant, anticancer and antitumor agents as well as antivirl. The main aim of the present thesis is focused on the preparation and characterization employing elemental analyses, thermal (TG and DrTG), spectral (IR, UV-Vis, 1H NMR ) and magnetic measurements of new complexes of diethyl 3,3’-(carbonylbis(hydrazin-2-yl-1-ylidene))(3E,3’E)-dibutyrate (H4EBC) with Cr(III), Mn(II), Fe(III), Co(II), Ni(II), Cu(II), Cd(II), Zn(II), Hg(II) and U(VI)O22+metal ions respectively. X-ray quality single crystals of unexpected product were obtained by slow evaporation of the filtrate obtained by the reaction with either SmCl3·6H2O or LnCl3·7H2O. A comparison of the experimental and theoretical spectra was carried out beside some other theoretical calculations. The biological activity was carried out. A brief description of the overall work in this thesis can be summarized as follow: Chapter one displays different publications concerning the complexion of hydrazine with a great attention to the compounds similar to that investigated and their biological activities as well as medical importance. The second chapter covers the experimental part and illustrates the experiments used in this work. It includes a list of reagents along with the physical measurements and instrumentation. The working procedures of computational studies were also discussed as well as a description for the preparation of the ligand and its metal complexes. In addition, this chapter includes the recommended procedures for the antioxidant, antimicrobial, DNA degradation and the antitumor activity of the prepared metal complexes. Most of complexes have high melting points ( >300˚C) and insoluble in most organic solvents. The geometries of complexes are suggested basically on the data evaluated from spectral and magnetic measurements.In order to assess the influenc of the structural properties of the ligands and the type of the metal on thermal behaviour of the complexes, the order (n) and the heat of activation (Ea) of the various decomposition stages are determined from the TG and DrTG using the coats-Redfern and Horowitz-Metzger methods. This section includes also the determination of the thermodynamic parameters of activation (ΔH*, ΔS* and ΔG*) which can be calculated by Erying equation. The molecular modeling are drawn and demonstrated both bond lengths and angles, chemical reactivity, MEP, NLO, Mulliken atomic charges, and binding energy (kcal/mol) for the investigated compounds. Theoretical infrared intensities of H4EBC was computed utilizing DFT technique to make a valuable assignment of the chemical shift. The final part in this chapter deals with the Antimicrobial antioxidant activity and the antitumor activity for H4EBC and their metal complexes.