الفهرس 
IntroductionOnly 14 pages are availabe for public view
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Abstract
Our results demonstrated that naringin, at a dose of 80 mg/kg b.w, can inhibit the adverse effects of CCl4-induced hepatic damage and can protect the cellular environments from radiation damage. Oral administration of naringin displayed important effects on the endogenous antioxidant system, blocked the main inflammatory cytokine IL-6, restored the miRNA expression and retained the normal ultra structure of the liver. Results showed that the hepatoprotective and radioprotective potential of naringin in rats is due to its antioxidant and anti-inflammatory potentials in a way comparable to that of silymarin. These actions make this flavonoid an effective compound to not only prevent but also to reverse hepatic damage induced by CCl4 and deleterious effects of γ radiation. Naringin shows promise for treating liver diseases because of its wide availability, low cost, variety of pharmacological actions and long history of use. Therefore, naringin may be a promising hepatoprotective agent against chemically-induced liver damage in vivo. MicroRNA-122 expression changes in hepatotoxicity and radiation exposure emphasizes the great value of miRNA signatures as hepatotoxicity and radiation biomarker.