الفهرس 
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Abstract
Introduction : Fish is considered the cheapest source of animal protein; therefore, most countries are paying a great attention to improve their inlet resources to satisfy their requirements of animal protein. Oreochromis niloticus (Nile tilapia) is the most popular cultured species among tilapia in many countries around the world. The Aim of this study: was carried out to evaluate the in vitro and in vivo antibacterial activity of Tomex® and Doxcymycin® against Aeromonas hydrophila pathogen in Oreochromis niloticus fish with special references to their effect on survival rate and to determine their effect on some hematological, biochemical, immunological and antioxidant parameters . In addition, the histopathological examination of tissue specimens’ (liver, spleen, gill, fins and skeletal muscle) of Oreochromis niloticus was performed. Materials and methods: One hundred and twenty (120) apparently healthy, Tilapia fish were obtained from a private fish farm in Kafr Al Shaikh Governorate with average body weight of 150 g. Fish were acclimatized for one week before beginning of experiment to minimize the possible stresses and make sure that all fish have been adapted to the same environmental condition. Results : Overall the comparison of the torque measurements between 3-D laser scanner and TIP device the readings showed that there is a statistically non-significant difference in all male study group except in upper central incisor and lower canine. While in female study group the readings obtained there is a statistically significant difference in all teeth between the two methods except upper and lower incisors. Conclusion: It could be concluded that, Garlic dose not have antibacterial effect against A.hydrophila in vitro but it had antibacterial, antioxidant and immunostimulant effects as shown in vivo. Doxycycline has a much treated effect during treatment of A.hydrophila infection in Nile Tilapia which improved the fish performance, with some transient changes in serum biochemical, heamatological parameters, immunological and antioxidant changes.