الفهرس 
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Abstract
This study aims to find modern non-chemical methods for those used in domestic production and export, as an alternative to methods of anti-fungi, anti-bacteria, essential oils, and mycostop protocols. Two types of antagonistic fungi, Trichoderma viride, T. harzianum, two types of bacteria, Bacillus subtiles, Pseudomonas fluorescence, were used in addition to Streptomyces griseoviridis(Mycostop).and one type of oil, Syzygium aromaticum. An open field experiment was conducted during the 2017 growing season, and a protected cultivation experiment was conducted during two consecutive growing seasons from 2017-2018 at Housh Issa Farm in Buhaira Governorate. In two stages, each stage represents one trial, the first was pre-infection experiment and the second was post infection experiment. 1- pre infection experiment (greenhouse). In this experiment, the spray was applied to plants before any symptoms development of downy mildew appeared on the leaves. The results of this experiment also showed the superiority of T. harzianum during different growth periods up to 90 days, as it gave an incidence 44.30% and disease severity of 19.26% compared to the control (the incidence of disease 100% and disease severity 83.89%). Regarding the chemical fungicide (the incidence rate of the disease was 66.67% and the severity of the disease was 25.93%). from the results obtained, it is evident that T. harzianum gave promising results better results than T. viride, and the other antagonistic and essential oil treatments. The growth measurements of the cucumber plant were estimated, as well as the chlorophyll content, carotene, total phenols, and dissolved solids during the planting season. The results showed that there were significant differences between most of the treatments. The most effective treatments were clove oil, and the best treatments affecting the fruit weights were T. viride. The percentage of total solids were the most effective treatments by T. harzianum, while mycostob and bacteria P. fluorescence were less effective on measurements from the rest of the transactions. 2- post infection experiment (greenhouse). In this experiment, the spray was applied to plants after the appearance of symptoms of downy mildew on the leaves. Under greenhouse conditions only, while no data was recorded from open field trials because of the absence of infection according to the low level of relative humidity. The results obtained here showed the superiority of T. harzianum during different growth periods up to 90 days, as the incidence of disease was 40% and disease severity was 31% compared to the control (the incidence in the controlwas 100% and severity was86.33%) and the chemical fungicide, the incidence of disease was 20% and disease severity 29.49%. While T. viride moderate results compared to the control, where the incidence of disease was 60% and disease severity 27.22%. The growth measurements of the cucumber plant were estimated as well as the chlorophyll content, carotene, total phenols, and dissolved solids during the planting season. The results showed that there were significant differences between most of the treatments. The attractive treatments were clove oil, and for the best effect on the fruit length was the chemical fungicide and on the weight of the fruits, was the bacteria P. fluorescence. The percentage of total solids was recorded for T. harzianum while mycostop and T. viride were less effective in this regard. This study summarizes information about disease progress under greenhouse conditions, and aspects of resistance to P. Cubensis. Finding safe, non-chemical methods to produce safe healthy cucumber production was considered. Accordingly, some antibiotic-producing organisms such as fungi, bacteria, and mycostop were used, as well as some oil plant extracts such as clove oil. In addition, various biological resistance methods aimed at developing short- and long-term control measures on downy mildew are discussed.