الفهرس 
Multinodular GoiterOnly 14 pages are availabe for public view
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Abstract
Background: Thyroid nodules are a common clinical problem affecting numerous individuals worldwide. The prevalence of palpable thyroid nodules is approximately 5% among women and 1% among men living in iodine-sufficient parts of the world. High-resolution ultrasound can detect thyroid nodules in 19%–68% of randomly selected individuals, with higher frequencies in women and the elderly.
Aim and Objectives: Study of The Relation between 8_Hydroxy-2’-deoxyguanosin (8_OHDG) and Suspicious Thyroid nodule in a Patients with Multinodular Goiter.
Subjects and Methods: Statistical presentation and analysis of the present study was conducted, using the mean, standard deviation and Student t-test [Unpaired, Linear Correlation Coefficient [r] Chi-square ANOVA by SPSSV17.
Result: All participant were subjected to full history taking, thorough clinical examination and Laboratory investigations including (TSH, free T3, free T4, serum 8-OHDG, Neck Ultrasonography, and FNA was done for those who had suspicious Ultrasonography criteria for thyroid nodule according to TIRADS classification TR3_TR5 (TR3:≥2.5 cm TR4: ≥1.5 cm TR5: ≥1 cm).
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Conclusion: In conclusion, our study confirms the presence of oxidative stress in patients with non-toxic multinodular goitre. The plasma 8-OHDG levels may be markers of the carcinogenic potential of multinodular goiter and could be used for early detection of different cancer types, including thyroid cancer. This warrants nutritional support with antioxidant agents in patients with non-toxic multinodular goiter. Further studies are warranted for better understanding of underlying pathogenic mechanism of oxidative stress in non-toxic Multi nodular goitre