الفهرس 
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Abstract
Objective: Evaluation of possible antiviral and immune stimulating effects of Aloe Vera on vvIBDV. Design: Experimental study. Samples: A reference vvIBDV virus strain (IBDV/Dakahlia, Egypt/2016) was used as a challenge strain. Procedures: A 10% Aloe Vera water extract (AVWE) was prepared then its antiviral effect against vvIBDV was tested in Embryonated chicken eggs (ECEs), five groups were created (Ge1-Ge5); Ge1 was a negative control, Ge2 was a positive control, Ge3, Ge4 and Ge5 were prophylactic, antiviral and treatment groups respectively. Whereas the immune stimulating effect of 10% AVWE was tested in chicks, five groups were created (Gc1-Gc5); Gc1 was a negative control, Gc2 was a positive control, Gc3, Gc4 and Gc5 were; protected, protected-treated, and treated groups respectively. Results: In ECEs, Ge2, Ge3 and Ge5 embryos showed typical vvIBDV lesions with high vvIBDV load in real time RT-PCR (RRT-PCR). While Ge1 and Ge4 embryos were normal and gave negative results in RRT-PCR. In challenged birds, Gc1 not developed any clinical signs or post mortem changes. Gc2 and Gc5 showed typical vvIBDV signs. Gc3 and Gc4 developed mild signs of depression and ruffled feathers. There was a statistically significantly lower body weight in Gc2 vs. all other groups. Gc4 gave the highest total leucocytic and lymphocytic counts. Gc4 also recorded highest antibody titer against vvIBDV with mild histopathological lesions. Conclusion and clinical relevance: AVWE (10%) has a potent antiviral effect against vvIBDV with no prophylactic or treatment effects in ECEs. On the other hand, the use of 10% AVWE before and after vvIBDV challenge in chicks gave a promising protective effect.