الفهرس 
IntroductionOnly 14 pages are availabe for public view
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Abstract
Vitiligo is a skin disorder that causes the skin to lose its color. Smooth white areas (called macules if less than 5mm or patches if 5mm or larger) appear on a person’s skin. Oxidative stress, defined as a pro-oxidant vs. antioxidant imbalance in favor of the first, plays an important role in all inflammatory skin diseases. Skin is the barrier organ that protects the human body from external threats. For this reason, it is subjected to constant exposure to ROS, which are responsible for keratinocyte damage. Cell damage leads to the release of pro-inflammatory mediators and recruitment of immune cells. When the endogenous antioxidant system fails to adequately reduce OS, thus a form of treatment with antioxidant properties could be a therapeutic option. Thus, a form of treatment with antioxidant properties could be a therapeutic option. The aim of the present study is to measure level of reactive oxygen species and total antioxidant capacity in Egyptian patients with early vitiligo. All patients in the present study were subjected to history taking, detailed general examination, dermatological examination, VASI Score Record (Vitiligo Area Scoring Index) and measurement of ROS and TAC. The present study show that : • Vitiligo group showed significantly higher level of ROS, significantly lower level of TAC when compared to control group (p<0.001 for each).