الفهرس 
INTRODUCTIONOnly 14 pages are availabe for public view
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Abstract
Mycotoxins are considered one of the most important problems that negatively affect poultry farms. Mycotoxins are secondary metabolites of some fungi that contaminate cereals and present public health risks.Many of antimycotoxins products have been appeared, including T-Nil®Plus and Synertox®, both of them are biological antimycotoxins. The aim of this study is to investigate the effects of T-Nil®Plus and Synertox® on performance, blood picture, some serum biochemical parameters and histopathological changes of liver, kidneys and duodenum. This study was conducted on 150 unsexed (one day old) chicks. these chicks were divided into 5 equal group (30 chicks per group) as follows: The first group (control group): no feed additives were used, the second group: chickens were medicated with T-Nil®Plus liquid orally in the drinking water from 1st till 10th day of age of bird at dose level 1ml/liter, the third group: chickens were medicated with T-Nil®Plus liquid orally in the drinking water from 15th till 24th day of age of bird at dose level 1ml/liter, the fourth group: chickens were medicated with Synertox® liquid orally in the drinking water from 1st till 10th day of age of bird at dose level 1ml/liter and the fifth group: chickens were medicated with Synertox® liquid orally in the drinking water from 15th till 24th day of age of bird at dose level 1ml/liter. The consumed feed was weighed daily for each group, also the birds of each group were weighed weekly for 5 weeks, the results proved that the second group showed that there were a significant decrease of body weight gain and feed consumption at 1st and 2nd week of the experiment, the third group revealed a significant increase in feed conversion ratio at 5th week of the experiment in comparison with control group, while Synertox® medicated groups revealed non-significant changes in body performance. As for blood pictures, the second group treated with T-Nil®Plus showed a significant decrease of red blood cells, hemoglobin concentration, packed cell volume , leucocytes at 14th day post treatment and a significant increase of lymphocytes at 7th and 14th day post treatment comparing with control group. While the third group caused a significant increase of red blood cells, hemoglobin concentration, packed cell volume at 1st and 14th days post treatment and a significant decrease of leucocytes on 14th day post treatment. Synertox® medicated groups showed a significant increase of red blood cells, hemoglobin concentration, packed cell volume at 1st day post treatment but a significant decrease of leucocytes were observed at 14th day post treatment. There were no significant alterations of red blood cell indices in all medicated groups when compared with control group. As for liver functions, the second group showed a significant increase in the level of (alanine amino transferase) and the ratio of albumin to globulin at 7th and 14th days post treatment but a significant decrease of (aspartate amino transferase) at 7th and 14th post treatment and total protein and globulin at 14th day post treatment while the third group showed a significant decrease in the level of (aspartate amino transferase) at 7th day post treatment but there were a significant increase in the level of (alanine amino transferase) at 1st and 7th days post treatment, while the fourth group showed a significant decrease of aspartate amino transferase levels at 1st and 7th days post treatment and globulin on 14th day post treatment, the fifth group revealed that a significant decrease of aspartate amino transferase levels at 1st and 7th days post treatment and globulin at 14th day post treatment aspartate amino transferase levels at 7th days post treatment and globulin at 14th day post treatment compared with control group. As for kidney function, the second group showed a significant increase of serum creatinine level at 1st day post treatment, while the third group showed a significant decrease of creatinine level at 7th day post treatment when compared with control group. Synertox® medicated groups revealed a significant increase of creatinine level at 7th day post treatment compared with control group. As for glucose level, there was a significant decrease for each of the third group treated with T-Nil®Plus and the fourth group treated with Synertox® at 7th and 14th days post treatment compared with control group. As for Anti oxidative stress factor (Reduced glutathione) and oxidative stress factors (Nitric oxide and Malondialdehyde), the third group showed a significant decrease of reduced glutathione level at 7th day post treatment and a significant increase of Malondialdehyde level at 1st day post treatment, while the fifth group showed a significant decrease of nitric oxide level at 14th day post treatment , while the fourth group revealed a significant increase of reduced glutathione level at 7th day post treatment and the fifth group revealed a significant increase of reduced glutathione level at 1st day post treatment in comparison with control group. The results also showed that each of the two products has some histopathological changes on tissues such as liver, kidney and duodenum. The results were discussed and compared with available research and references. from the previous results, we can conclude that giving Synertox® at any time of the experiment has a positive effect on performance of broilers because it leads to a good feed conversion rate and increases the bird’s immunity against oxidative stress because it increases the level of reduced glutathione rather than T-Nil®Plus.