الفهرس 
IntroductionOnly 14 pages are availabe for public view
 |  | from | 146 |  |  |
| | | from | 146 | | |
Abstract
”The Possible Protective role of graviola leaf extract against Ccl4 hepatotoxicity in male albino rats The objective of the current study was to establish the protective effect of Graviola Leaf Extract (GLE) against Carbon tetrachloride (CCl4) hepatotoxicity in male albino rats. Rats were divided randomly into four groups, each one contains 10 rats as follows: group 1(control): rats received distilled water; group 2 (GLE): rats received GLE (200 mg / kg bw) through oral administeration daily for one month; group 3 (CCl4): rats received CCl4 (1ml / kg bw) intraperitoneal administeration as single dose in the last day in the experiment; group 4 (GLE+ CCl4): rats received GLE and CCl4 as group 2 and 3. The obtained results showed significant increase in hepatic enzymes (AST, ALT) and TB in serum and also showed significant increase in oxidative stress markers (MDA) as well as significant decrease in serum Alb and in antioxidant parameters (GSH, SOD, CAT) in CCl4 treated group, it also causes significant increase in proinflammatory cytokines level (IL-1β, TNF-α) and in apoptotic markers (Bax, caspase-3) which are important control factors of apoptosis and caused a significant decrease in anti-apoptotic protein (Bcl 2), as well as it caused DNA damage and significant increase in (Tail moment, Tail length, Tail DNA), also in histology examination it showed hepatic tissue damage. On the other hand, GLE administration significantly improved the deviation resulting from CCl4 in nearly all parameters. Ultimately, it could be concluded that GLE able to reduce the hepatic damage caused by CCl4 and GLE should be taken as a protective agent against hepatotoxicity.”