الفهرس 
Introduction and aim of the workOnly 14 pages are availabe for public view
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Abstract
Colon cancer is the third most common cancer, there are previous studies demonstrated that nanocurcumin is safely used against different cancers and more effective than normal curcumin(CUR). Our study aim is studying the protection effect of CUR-encapsulated poly (lactic-coglycolic acid) (PLGA) nanoparticles (CUR@PLGA) against colon carcinogenesis induced by dimethyl hydrazine (DMH) in mice. Also performed to evaluate the potential effect of nanoparticles for enhancing CUR bioavailability. The mice were randomly divided into 6 groups. The control group. The DMH group. The CUR group, CUR@PLGA group, DMH and CUR group and DMH and CUR@PLGA group. The animals were sacrificed at the end of 6 weeks. The results showed using CUR@PLGA made a significant improvement in the level of oxidative stress markers and anti-oxidants. CUR@PLGA showed significant increase in tumor protein P53 level, caspase 3 and Bcl-2 associated X protein (BAX) also significant decrease on B cell lymphoma 2 (Bcl-2) level. The Aberrant crept foci (ACF) that represent the first stage on colon carcinogenesis is significantly reduced in number on CUR@PLGA group. Our study reveals that CUR@PLGA have a great effect on antioxidants, apoptotic proteins and ACF. So, it provides an insight towards the use of biological sources as promising anticancer agents.