الفهرس 
IntroductionOnly 14 pages are availabe for public view
 |  | from | 131 |  |  |
| | | from | 131 | | |
Abstract
In ESRD patients, CVD is the leading cause of death.Premature cardiac death has become epidemic in the dialysis population around the world.However, it has recently become clear that SCD, rather than myocardial infarction and coronary events, is the leading cause of increased cardiovascular mortality in patients with ESRD, accounting for up to 40% of all deaths and 78 % of cardiovascular deaths.Renal failure patients on long-term HD frequently experience ventricular arrhythmias. A significant portion of HD patients’ cardiovascular mortality may be due to associated ventricular arrhythmias. The index of cardiac-electrophysiological balance is a new non-invasive marker that can predict ventricular arrhythmias. The cardiac wavelength (= effective refractory period [ERP] conduction velocity [CV]) is thought to be equivalent to the iCEB. Several studies have reported the value of ICEB in different sets of patients, However, only few studies have evaluated its role in patients maintained on HD.The present study aimed to evaluate the iCEB in prevalent HD patients and to explore its relation to the cardiovascular outcomes.The present study revealed that patients’ age has no major influence on iCEB. Furthermore, the present study showed that gender has no major influence on iCEB.As well, none of the studied blood pressure measurements; systolic, diastolic, and mean arterial blood pressure significantly statistically correlated to iCEB.The current study found no significant relationship between dialysis parameters such as blood flow rate, ultrafiltration volume, dialysis duration, and number of dialysis sessions per week on the one hand, and the iCEB on the other.In the current study, changes in iCEB were significantly correlated with dialysis-related hypotension. The present study revealed positive significant correlation between the PTH levels and iCEB.In the present study, Death occurred in 31.1, arrythmia in 25.5 % and MI was reported in 26.9 % of the included patients. iCEB at cut point ≤4.08 has 94.50% specificity and 86.41 sensitivity in predicting arrythmia.As well, the study showed that iCEB at cut point ≤4.67 has 63.38% specificity and 72.66 sensitivity in predicting mortality in HD patients.The study also showed that iCEB at a cut point ≤4.75 has 64.78% specificity and 86.49 sensitivity as a predictor of MI in HD patients.It has been apparent from the present work that iCEB can predict the major cardiovascular outcomes in HD patients and thus may have a future role in anticipating fatal arrythmias, however further studies are warranted to confirm our result.