الفهرس 
Introduction & Aim of the WorkOnly 14 pages are availabe for public view
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Abstract
Liver fibrosis is a threatening health problem leading to development of cirrhosis and liver cancer. At present, there are no direct medications targeting the attenuation or inhibition of liver fibrosis. So many studies were directed to use natural products in order to manipulate liver fibrosis. The present study aimed to evaluate the prospective hepatoprotective mechanisms of sesamol (SML) and betanin (Bet) in thioacetamide (TAA)-induced liver fibrosis in rats via investigating their effects on LPAR1, LPAR3 gene expressions and study the ability of SML and Bet to inhibit TGF-β1/Smad pathway. Moreover, SML’s and Bet’s abilities to ameliorate ductular reaction and angiogenesis were investigated. from this study, we conclude that 1. Both SML and Bet represent natural products which have significant hepatoprotective activities that may support their use as a dietary supplement to protect against liver fibrosis. 2. The anti-fibortic and the heptoprotective activites of SML and Bet may be attirubuted to the following molecular mechanisms : a) Both SML and Bet have significant anti-oxidant activities. b) The ability of SML and Bet to inhibit TAA-induced upregulation of LPAR1/3 and TGF-β1/Smad3 signaling pathway that may lead to inhibition of hepatic stellates cells activation and proliferation. 3. SML and Bet not only decrease ductular reaction but they also reduce angiogenesis.