الفهرس 
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Abstract
Cisplatin is one of the most commonly used chemotherapy agents in the treatment of various types of cancer. Cisplatin has caused toxicity to the liver, heart, and kidneys. The primary objective of this study is to investigate the protective and therapeutic effect of omega-3 on cardio and nephrotoxicity induced by cisplatin. This experiment was conducted on fifty healthy male white rats, weighing about 200-230 g. The rats were divided into 5 groups, first group (control) served as a negative control group, second group (cisplatin) received cisplatin (10 mg/kg) as a single dose intraperitoneally,Third group (omega-3) received a dose of omega-3 (200 mg/kg) via intragastric tube once daily for six weeks. Fourth (therapeutic) group received a single dose of cisplatin intraperitoneally (10 mg/kg) and then a dose of omega-3 (200 mg/kg) via intragastric tube daily for six weeks. Fifth (protective) group received a dose of omega-3 (200 mg /kg) via intragastric tube once daily for six weeks with a single dose of cisplatin (10 mg/kg) intraperitoneally at the beginning of fifth week of the experiment. Samples were collected to perform tests. The cisplatin group and the treatment group showed a decrease in body weight, increase in liver weight, and no change in the weight of the kidneys and heart. The results showed increase in liver enzymes (ALT &AST) and a decrease in the percentage of albumin, as well as increase in kidneys parameters (Cr&UA), results of heart showed increase in (CK-MB & LDH), and it showed an increase in (TAG, CH ,LDH), with no change in (HDL). For oxidative stress, there is an increase in (MDA) and a decrease in (GSH, CAT&SOD). Also, histopathological analyzes confirmed the occurrence of changes in the tissue of heart and kidneys. Treating rats with omega-3 resulted in improvement in all previous parameters, this indicates that it has protective and therapeutic effect on cisplatin-induced toxicity. Coclusion from this study: administration of cisplatin as a single intraperitoneal dose (10 mg/kg) caused hepatic, cardiac and renal toxicity. Cisplatin is cytotoxic by increasing oxidative stress and depleting the body’s antioxidant reserves. Omega-3 can be used as an additive as it improve liver, heart and kidney function in normal rats. Omega-3 improves lipid profile and antioxidant reserves in normal rats. Omega-3 has a protective and therapeutic effect On hepatic, cardiac and renal toxicity induced by cisplatin. Omega-3 has protective effects on cisplatin toxicity and was more pronounced than the therapeutic effect.