الفهرس 
CHAPTER I: INTRODUCTIONOnly 14 pages are availabe for public view
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Abstract
The concerned compounds were synthesized using aryl amines 14a, b which were converted into the corresponding aryl aizdes 15a, b. The prepared aryl azides were converted into 1,2,3-triazole derivatives 16a, b which were converted finally into the designed compounds 17a, b. In the current work, (E)-1-(1-(4-substphenyl)-5-methyl-1,2,3-triazol-4-yl)-3-(3,4,5-trimethoxyphenyl)prop-2-en-1-one 17a,b were obtained from Claisen-Schmidt condensation of acetyl triazoles 16a, b with 3,4,5-trimethoxy benzaldehyde in ethanolic solution of NaOH. All the prepared compounds were characterized by using FT-IR and 1H-NMR and 13C-NMR where needed. Anti-cancer activity of the prepared chalcones 17a, b was investigated by National Cancer Institute and showed promising results as anticancer candidates. Compounds 17a, b were uploaded into Chitosan (CS) and Carboxymethylcellulose (CMC) as polymeric carriers and converted into the corresponding polymer blends through physical mixing. The release behavior of chalcones 17a, b from their polymer blends into aqueous medium at room temperature was investigated and the obtained results were summarized and discussed.