الفهرس 
IntroductionOnly 14 pages are availabe for public view
 |  | from | 98 |  |  |
| | | from | 98 | | |
Abstract
Psoriasis is a complex chronic inflammatory skin disease mediated by Th1, Th17, and Th22 lymphocytes with production of large amounts of proinflammatory cytokines. Individuals with severe psoriasis have an increased risk of heart attack and this risk is independent of other major risk factors such as hypertension, diabetes, obesity, dyslipidemia and smoking which are also common in psoriasis. Increased prevalence of cardiovascular disease appears to be highest for those with more severe psoriasis (Gelfand et al., 2006). 1. Aim of this study: This work was made for estimation of serum level of N-terminal Pro-B-type natriuretic peptide, as a predictor of cardiovascular disease, in psoriasis patients and compare it with healthy non psoriatic controls. .Subjects and methods: A case-control study enrolled 50 patients with psoriasis vulgaris and 40 healthy age- and sex-matched controls. N-terminal Pro B-type natriuretic peptide level was measured in venous blood samples using ELISA. Results: Higher Pro BNP level was detected among patients versus controls. A statistically significant difference was found between patients and controls as regard Pro BNP (P<0.001). These findings might indicate possible relation between psoriasis and cardiovascular disease. Conclusion: •Increased levels of NT-proBNP were seen in the studied psoriatic individuals, supporting the possibility of utilizing this biomarker to predict CV hazard in people with psoriasis. Keywords: Psoriasis, NT-proBNP, Cardiovascular (CV).