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العنوان
Synthesis of some new triazenes and related Aryl-azo derivatives /
المؤلف
Egeela, Sonia Samy Tolba.
هيئة الاعداد
باحث / سونيا سامي طلبه عجيله
مشرف / السيد محمد عفصة
مشرف / إبراهيم عبدالجليل عبدالسلام
مناقش / حاتم السيد جعفر
مناقش / هالة محمد رفعت
الموضوع
Organic Chemistry.
تاريخ النشر
2023.
عدد الصفحات
online resource (148 pages) :
اللغة
الإنجليزية
الدرجة
ماجستير
التخصص
Organic Chemistry
تاريخ الإجازة
1/1/2023
مكان الإجازة
جامعة المنصورة - كلية العلوم - قسم الكيمياء العضوية
الفهرس
Only 14 pages are availabe for public view

from 148

from 148

Abstract

Part I: Synthesis of some new Phenolic triazenes and Bis(triazenes): In this part, the synthesis of a new series of phenolic triazenes incorporating a heterocyclic moiety has been achieved by treating p-hydroxyphenyl diazonium chloride with the appropriate heterocyclic secamine. Therefore, N-coupling with piperidine, morpholine, tetrahydroisoquinoline and 3,3,5-trimethylhexahydroazepine lead to the formation of phenolic triazene derivatives. Part II. Synthesis of Arylazo-triazene Hybrids Coupling of aryl diazonium salts with phenolic triazenes: In this part, coupling of the appropriate diazonium chloride with 4-(piperidin-1-yldiazenyl)-phenol, afforded a series of compounds .In line with this, coupling of bis(diazotized) p-phenylenediamine with 4- (piperidin-1-yldiazenyl)-phenol, led to the formation of 2,2’-(1,4-phenylenebis(diazene-2,1-diyl))bis(4-(piperidin-1-yldiazenyl)phenol). The coupling reaction of 2-(aryldiazenyl)-4-(piperidin-1- yldiazenyl)-phenols of the type 18a with diazonium ions is of particular interest. For instance, coupling of 4-(piperidin-1-yldiazenyl)-2-(p-tolyldiazenyl)phenol (18a) with aryl diazonium ions derived from p-aminophenol and p-anisidine afforded 2-(4-hydroxyphenyl)diazenyl)-4-(piperidin-1-yldiazenyl)-6-(p-tolyldiazenyl)phenol and 2-(4-methoxyphenyl)diazenyl)-4-(piperidin-1- yldiazenyl)-6-(p-tolyldiazenyl)phenol, respectively
Part III: Biological Activity: Antioxidant activity: All the constructed compounds were tested as antioxidant agents and the results which were summarized showed that compounds 3, 4, 5, 6, 9, 11, 18b, 22, 30, 31 and 39 exhibited the highest inhibition value antioxidant screening. On the other hand, the other evaluated products showed moderate to low inhibition values Antimicrobial activity (antibacterial and antifungal): The investigations of antimicrobial screening data indicated that compound 3, 6 and 30 exhibited the highest inhibition value with respedt to E. coli. Furthermore, compound 3, 4, 5, 6 9, 11, 13, 30, 31 and 39 exhibited the highest inhibition value with respedt to S. aureus. Additionally, compound 3, 4, 6, 11, 13, 30, and 31 exhibited the highest inhibition value with respedt to C. Albicans. On the othar hand, most of other newly synthesized compounds exhibited fair to good antimicrobial activities compared to that of the standard drugstudy.