الفهرس | Only 14 pages are availabe for public view |
Abstract Part I: Synthesis of some new Phenolic triazenes and Bis(triazenes): In this part, the synthesis of a new series of phenolic triazenes incorporating a heterocyclic moiety has been achieved by treating p-hydroxyphenyl diazonium chloride with the appropriate heterocyclic secamine. Therefore, N-coupling with piperidine, morpholine, tetrahydroisoquinoline and 3,3,5-trimethylhexahydroazepine lead to the formation of phenolic triazene derivatives. Part II. Synthesis of Arylazo-triazene Hybrids Coupling of aryl diazonium salts with phenolic triazenes: In this part, coupling of the appropriate diazonium chloride with 4-(piperidin-1-yldiazenyl)-phenol, afforded a series of compounds .In line with this, coupling of bis(diazotized) p-phenylenediamine with 4- (piperidin-1-yldiazenyl)-phenol, led to the formation of 2,2’-(1,4-phenylenebis(diazene-2,1-diyl))bis(4-(piperidin-1-yldiazenyl)phenol). The coupling reaction of 2-(aryldiazenyl)-4-(piperidin-1- yldiazenyl)-phenols of the type 18a with diazonium ions is of particular interest. For instance, coupling of 4-(piperidin-1-yldiazenyl)-2-(p-tolyldiazenyl)phenol (18a) with aryl diazonium ions derived from p-aminophenol and p-anisidine afforded 2-(4-hydroxyphenyl)diazenyl)-4-(piperidin-1-yldiazenyl)-6-(p-tolyldiazenyl)phenol and 2-(4-methoxyphenyl)diazenyl)-4-(piperidin-1- yldiazenyl)-6-(p-tolyldiazenyl)phenol, respectively Part III: Biological Activity: Antioxidant activity: All the constructed compounds were tested as antioxidant agents and the results which were summarized showed that compounds 3, 4, 5, 6, 9, 11, 18b, 22, 30, 31 and 39 exhibited the highest inhibition value antioxidant screening. On the other hand, the other evaluated products showed moderate to low inhibition values Antimicrobial activity (antibacterial and antifungal): The investigations of antimicrobial screening data indicated that compound 3, 6 and 30 exhibited the highest inhibition value with respedt to E. coli. Furthermore, compound 3, 4, 5, 6 9, 11, 13, 30, 31 and 39 exhibited the highest inhibition value with respedt to S. aureus. Additionally, compound 3, 4, 6, 11, 13, 30, and 31 exhibited the highest inhibition value with respedt to C. Albicans. On the othar hand, most of other newly synthesized compounds exhibited fair to good antimicrobial activities compared to that of the standard drugstudy. |