الفهرس 
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Abstract
Multiple sclerosis (MS) is a chronic inflammatory disease which affects the central nervous system. Memory deficits are commonly found in MS. According to current memory models, the hippocampus plays a critical role in the formation of new episodic memories. Patients and Methods: A convenient sample of 60 cases of RRMS and 60 age & sex matched-healthy controls were recruited over 1 year. All patients were subjected to thorough medical and neurological examination, routine laboratory investigations and EDSS ”Expanded Disability Status Scale”. The 2 groups completed a subjective memory complaint questionnaire. An objective memory composite was derived from the Mini-Mental State Examination (MMSE) and the Montreal Cognitive Assessment (MoCA). Cases had hippocampal volumetry. Brain MRI was performed on a 1.5T Siemens Aera, Germany, and closed-configuration whole body scanner using a standard quadrature head coil. Results: This study showed no statistically significant difference between studied groups as regard age, sex and education. Age of our cases ranged between 20-40 years with mean age of cases was 31.27 years versus 29.02 among controls. Among both cases and controls; 66.7% were females and 33.3 were males. Among cases; 43.3 % had high school education, 43.3% graduated from college and 13.3% had only 8th grade education. Among control group; 48.3% had high school education, 35% graduated from college and 16.7% had only 8th grade education. Median disease duration among cases was 2 years ranging from 3 days to 13 years. This study showed that median EDSS among studied cases was 3 ranging from 0 to 8. This study illustrated that median Subjective Memory Complaints Questionnaire was 4 among cases ranging from 0 to 12 with 26 (43.3%) of cases had significant complaints. This study demonstrated that MMSE score was ranged between 17-30 with mean 27.6 among cases with 6 (10%) of cases had mild CI and 2 (3.3%) of cases had severe CI. This study showed that MoCA score ranged between 15-30 with mean score was 23.43 among cases with 24 (40%) had mild CI and 8 (13.3%) had moderate CI. This study showed that there was no statistically significant correlation between Subjective memory complaints questionnaire, MMSE score, MoCA score and hippocampal volume. This study showed a statistically significant positive correlation between duration of disease and Subjective memory complaints questionnaire (r=0.525, p=0.001). A statistically significant negative correlation was detected between disease duration and MMSE score (r=-0.404, p=0.001) and between disease duration and MoCA score (r=-0.310, p=0.016). This study illustrated non statistically significant correlation between EDSS and SMCQ (r=0.099, p=0.601), between EDSS and MMSE (r=-0.186 m, p=0.325), between EDSSS & MOCA (r=-0.181, p=0.338), between right, left relative hippocampal volume and EDSS (r=0.137, p=0.469 & r=0.168, p=0.374). Conclusion: Disease duration had impact on cognitive state, as longer disease duration gave more cognitive dysfunction, but no correlation was found between cognitive impairment and hippocampal volumetry. According to our data, we conclude hippocampal volume assessment did not predict the cognitive affection in patient with RRMS. Keywords: RRMS, volumetry, cognitive, hippocampus