الفهرس 
Aim of the workOnly 14 pages are availabe for public view
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Abstract
Cancer is a devastating problem leading to morbidity and mortality all over the world especially in Egypt. Its incidence varies globally and is closely linked to elements of so called western life style as alcohol, smoking, low physical activity, and gene mutations. There are many different treatment methods, and the appropriate method is chosen according to the patient’s condition, including chemotherapy, radiotherapy, surgical intervention, and recently immunotherapy. Moreover cancer can be cured if it discovered in early stage, or can be minimized by changing life style and eating healthy food. The present study was planned to evaluate the effect of natural products as ginger and luteolin on Erlich Ascities Carcinoma (EAC) induced mice. A total of 56 healthy Female Swiss albino mice were divided into 7 groups as follows: • group 1: serving as control group, given commercial diet and tab water only (negative control). • group 2: mice orally given a dose of 200mg/kg. b.w. / day of ginger crude ethanolic extract for 2 weeks beside normal diet and water. (negative ginger) • group 3: mice orally given a dose of 50 mg/kg. b.w. / day of g LUT for 2 weeks beside normal diet and water. (negative LUT) • group 4: mice will be injected once intraperitoneally by Ehrlich cells 2x106 cells to induced Ehrlich tumor development. (EAC) • group 5: Ehrlich cells (2x106) intraperitoneally injected mice will be kept for two weeks till tumors volume reaches 1 mm3. After that, mice were then given an oral dose of 200mg/kg. b.w. / day of ginger for extra two weeks. (EAC+G) • group 6: Ehrlich cells (2x106) intraperitoneally injected mice will be kept for two weeks till tumors volume reaches 1 mm3. After that, mice were then given an oral dose of 50mg/kg. b.w. / day of LUT for extra two weeks. (EAC+L) • group 7: Ehrlich cells (2x106) intraperitoneally injected mice will be kept for two weeks till tumors volume reaches 1 mm3. After that, mice were then given an oral dose of 200mg/kg. b.w. / day of ginger and 50mg/kg. b.w. / day LUT for extra two weeks. (EAC+G+L) After 4 weeks of the starting the experiment, blood samples were collected for biochemical and histopathological examination. Our results show that: • Significant increase in Caspase_3 level and decrease in B-cl2 in the treated groups 5,6,7 compared to untreated groups. • Significant increase in VEGF and Ki-67 level in group 4 (untreated). • Increase in liver enzymes in untreated groups compared with treated groups, which show near normal values. • Our histopathological examination of liver tissues is in agreement with the biochemical analysis. Our results prove that ginger and LUT has a powerful anti-cancer activity and induce apoptosis through significantly activating caspase-3 as well as significantly decreasing Ki-67 and Bcl-2 expression, which causes cell cycle arrest and inhibition of proliferation.