الفهرس 
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Abstract
Purpose: The study aimed to study the expressions and biological functions of miRNA190, miRNA-588 and miRNA-802 to understand the development and progression of LC and to investigate their role as predictors of LC late stages. Subjects and methods: sixty LC patients were involved. 60 tissue specimens obtained from laryngeal cancer as the laryngeal cancer group in addition to 30 tissue specimens were obtained from adjacent non-cancerous tissue as the control group after laryngectomy. The current research investigated the expressions of miRNA190, miRNA-588 and miRNA802 in tissue specimens by miRNeasy minikit for total RNA extraction and reverse transcription real-time quantitative polymerase chain reaction. Results: There was no statistically significant difference in miRNA-190 expression level while the expression levels of miRNA-588 and miRNA-802 were significantly lower in the LC group.There were no statistically significant differences in miRNA-190 and miRNA588 expression levels between early and late stages whereas, miRNA-802 expression level was significantly lower in the late stages. Multivariable analysis revealed that only stridor and Cx lymphadenopathy were statistically significant. Patients with Cx lymphadenopathy had 1.269 times higher odds to exhibit late stages of LC and patients with stridor had 1.459 times higher odds to exhibit late stages. ▪ Conclusion: MiRNA-588 and miRNA-802 showed a tumor suppressor role in LC with the possibility of their usage as biomarkers differentiating cancerous and healthy tissues. MiRNA-802 might play a protective role against progression to late stages of laryngeal cancer. Stridor and Cervical lymphadenopathy might serve as independent predictors of laryngeal cancer late stages. Key words: Laryngeal cancer, MiRNAs expression, Late stage prediction.