Search In this Thesis
   Search In this Thesis  
العنوان
Lichen planus and hepatitis C virus (HCV) :
المؤلف
Seleem, Mohamed Khaled Galal.
هيئة الاعداد
باحث / محمد خالد جلال سليم
مشرف / ليلى أحمد شرف
مشرف / ألبرت برنارد أكرمان
مشرف / نوال عبدالجليل غريب
مشرف / زينب عبدالعظيم إبراهيم
الموضوع
Lichen planus. Lichen planus - HCV genotypes - Evaluation. Lichen planus - Prevalence. Hepatitis C virus - Prevalence.
تاريخ النشر
2003.
عدد الصفحات
125 p. :
اللغة
الإنجليزية
الدرجة
الدكتوراه
التخصص
الأمراض الجلدية
تاريخ الإجازة
01/01/2003
مكان الإجازة
جامعة المنصورة - كلية الهندسة - Department of dermatology and andrology and stds
الفهرس
Only 14 pages are availabe for public view

from 142

from 142

Abstract

The aim of our work was to study the relation between HCV and LP to prove or disprove a possible role of HCV in the pathogenesis of LP.
The present work was conducted on two groups of patients. One group of 96 LP patients (49 males and 47 females) with age range from 12 to 75 years. All the patients were diagnosed by thorough history taking, complete clinical examination and pathological confirmation. Another group of 50 patients (age and gender-matched) with newly diagnosed untreated skin conditions other than LP (and not related in their pathogenesis to HCV) was randomly assigned as control group. Both groups were subjected to blood sampling for routine liver function tests and HCV antibodies testing with ELISA (Enzyme-Linked Immuno-Sorbent Assay). Positive cases of HCV antibodies were confirmed by serum testing for HCV antigens by PCR (polymerase chain reaction) and HCV serotyping of +ve HCV cases (by PCR) as an index of the underlying HCV genotypes.
from these results we can conclude that:
•There is definite relationship between HCV and oral lichen planus either erosive or non-erosive.
•Oral lichen planus (either erosive or non-erosive) could be taken as a clue to the possible presence of HCV infection (to search for its presence).
•There is no relation between either the onset, course or distribution of LP and the possible presence of HCV infection.
•There is no relation between cutaneous lichen planus and HCV (including the ordinary, actinic and hypertrophic types of lichen planus).
•It is concluded that no specific HCV genotype could be related to the pathogenesis of lichen planus.
•HCV genotype no (4) is the predominant HCV genotype in Egypt.