الفهرس 
Etiological and risk factorsOnly 14 pages are availabe for public view
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Abstract
Objective: Recurrence after apparently complete resection is one of the most relevant problems of meningioma treatment. The mechanisms of which are still unclear. Purpose of the study: The aim of this study is to correlate immunohistochemical expression of progesterone receptors, cyclin D1, and KI67/MIB-1 with meningioma recurrence. Methods: 153 cases of completely resected meningiomas have been reviewed. Immunohistological studies include Ki-67 LI, progesterone receptors, and cyclin D1. All these factors have been correlated with the recurrence. Results: The recurrence rate was 7.5%, 56.25%, 33.3% for WHO grade I, grade II, and grade III tumours respectively. The tumor recurrence was not significantly correlated with PR and cyclin D1 status. However, Ki-67 LI was significantly correlated with the recurrence (P<0.001). Non-recurrent cases had a mean KI67 LI of 3.47 ± 4.21% (range, 0-25), while that of recurrent cases was 16.75 ± 7.61% (range, 6-40). Conclusions: WHO grade and proliferative index (KI67 LI) are statistically significant to predict recurrence, while PR and cyclin D1 status are not.