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تصفح المحتوي RDA
التصفح حسب الموضوعات
التصفح حسب اللغة
التصفح حسب الناشر
التصفح حسب تاريخ النشر
التصفح حسب مكان النشر
التصفح حسب المؤلفين
تصفح الهيئات
التصفح المؤتمرات
التصفح حسب نوع المادة
التصفح حسب العلاقة بالعمل
تم العثور علي : 36
 تم العثور علي : 36
  
 
إعادة البحث

Thesis 2023.
Mahmoud, Mona Ahmed.
615 علم الصيدلة والعلاج  
The goal of the current thesis was to formulate niosomes of acemetacin (ACM) and
mefenamic acid (MEF) and developed them to improve their tumor targeting in
addition to radio-kinetic evaluation performed using 131I. Niosomes were prepared by
ether injection method and characterized for particle size (PS) - polydispersity index
(PDI) - zeta potential (ZP) - entrapment efficiency (EE%) and in vitro drug release.
Factors affecting radiolabeling with 131I were studied and optimized. Radio-kinetic
evaluation was done for 131I-ACM optimum niosomal and 131I-MEF optimum niosomal
formula by intravenous (I.V) administration to solid tumor bearing mice and compared
to I.V 131I-ACM solution and I.V 131I-MEF solution as a control - respectively. The
average droplet size - zeta potential and in vitro release after 24 h for the optimum ACM
niosomal formula were 315.23 ± 5.37 nm - − 9.16 ± 2.91 and 76 % - respectively. The
greatest labeling yield of 131I-ACM was 93.1 ± 1.1%. Radio-kinetic evaluation showed
a maximum tumor uptake of 5.431 %ID/g for 131I-ACM niosomal formula and 2.601
%ID/g for 131I-ACM solution at 60 min post I.V. injection. While the average PS and
ZP values for the optimum MEF niosomal formulation were 247.23 ± 2.32 nm and –
28.3 ± 1.21 - respectively. In vitro release study of the optimum formula showed
appropriate cumulative drug release of (77.73 %) after 24 hr. The highest labeling yield
of 131I-MEF was 98.7  0.8%. The biodistribution study revealed that the highest tumor
uptake of 131I-MEF niosomal formula and 131I-MEF solution at 60 min after I.V.
injection were 2.73 and 1.94 % ID/g - respectively.
As a conclusion - ACM-loaded niosomes and MEF-loaded niosomes are excellent
substitutes in cancer treatment due to enhanced tumor uptake of 131I-ACM and 131IMEF
by passive targeting of the nanosized niosomes - which was confirmed by
radiokinetic evaluation - Pharmaceutics - Nano
تصفح الوعاء  

Thesis 2022.
Mark Youssef Soliman,
617 الجراحة والموضوعات ذات الصلة  
general surgery
تصفح الوعاء  

Thesis 2015
Sanya Zakarya Mohammed
Sanya Zakarya Mohammed ,
تصفح الوعاء  

Thesis 2022.
Maha Mohammed Mahmoud Mohammed ,
610 الطب والعلوم الطبية   610 الطب والعلوم الطبية  
Gynecology and Obstetrics
تصفح الوعاء  

Thesis 2021.
هناء محمد سيد،
610 الطب والعلوم الطبية   610 الطب والعلوم الطبية  
التمريض
تصفح الوعاء  

Thesis 2022
Darwish,Heba Ahmed Abd Allah
617 الجراحة والموضوعات ذات الصلة  
تصفح الوعاء  

Thesis 2021
Abo-zeid,Tamer Mostafa Abdel
611 التشريح البشري، وعلم الخلية، وعلم الأنسجة  
HCC is one of the aggressive malignancies - and it remains one of the difficult
tumors to treat. Many studies have shown that hyperthermia treatment is an effective
method especially if combined with chemotherapy or radiotherapy in a variety of solid
tumors. Finding the proper mechanism working in such combination is still a great
challenge. Although there are a great number of researches on the therapeutic role of
hyperthermia - there is little certainty about its effect on the process of angiogenesis which
plays a vital role in tumor formation and maintenance. This study is focusing the
combination of hyperthermia and radiation and its anti-cancer activity of (antiproliferative -
anti-angiogenic and pro-apoptotic) through investigating the cytotoxic
effect of combined therapy on HepG2 cancer cells
Genetic Engineering and Biotechnology Research Institute

Thesis 2021.
Ali, Heba Abd El-Fattah Ahmed.
624 الهندسة المدنية  
تصفح الوعاء  

Thesis 2017
Mohamed Mohamed Abdelsalam,Mahmoud.
616 الأمراض  
Recent studies started to give attention to possibility of increase the level of prolactinin psychotic patients prior to administration of antipsychotics - the relationship between dopamine - prolactin and psychosis is more complicated than it looks.
This study aimed at comparing prolactin serum levels - using highly sensitive assays - between drug-naïve psychotic patients - matched healthy controls and on treatment group and investigating the relationship between the prolactin levels and predominance of positive or negative psycopathological domains of psychosis.
This observational cross-sectional case control study was performed in the outpatient clinic and inpatient ward of psychiatric department - Zagazig University Hospitals - Sharqia - Egypt.
A sample of 23 naive-patientswith the diagnosis of psychoticdisorders that fulfills the inclusion criteria was recruited by systematic random sampling technique until the sample size was reached. A control sample of 23 apparently healthy volunteers was recruited by the same technique from the hospital visitors and relatives of other patients - in addition to 23 patients on treatment already recruited by the same technique.
The diagnosis of psychotic disorders was based on the Semi-Structured Clinical Interview (according to DSM-5) from which data as age - sex - employment status - marital status - residence - education - personal - present and past history were collected followed by thorough mental state examination.
The predominance of positive or negative domain of psychopathology was rated using positive and negative syndrome scale (PANSS). Weight and height were measured to determine BMI and blood samples were collected - centrifuged and serum samples were frozen and stored until they were analyzed for prolactin levels.The data collected were statistically analyzed.
Recent studies started to give attention to possibility of increase the level of prolactinin psychotic patients prior to administration of antipsychotics - the relationship between dopamine - prolactin and psychosis is more complicated than it looks.
This study aimed at comparing prolactin serum levels - using highly sensitive assays - between drug-naïve psychotic patients - matched healthy controls and on treatment group and investigating the relationship between the prolactin levels and predominance of positive or negative psycopathological domains of psychosis.
This observational cross-sectional case control study was performed in the outpatient clinic and inpatient ward of psychiatric department - Zagazig University Hospitals - Sharqia - Egypt.
A sample of 23 naive-patientswith the diagnosis of psychoticdisorders that fulfills the inclusion criteria was recruited by systematic random sampling technique until the sample size was reached. A control sample of 23 apparently healthy volunteers was recruited by the same technique from the hospital visitors and relatives of other patients - in addition to 23 patients on treatment already recruited by the same technique.
The diagnosis of psychotic disorders was based on the Semi-Structured Clinical Interview (according to DSM-5) from which data as age - sex - employment status - marital status - residence - education - personal - present and past history were collected followed by thorough mental state examination.
The predominance of positive or negative domain of psychopathology was rated using positive and negative syndrome scale (PANSS). Weight and height were measured to determine BMI and blood samples were collected - centrifuged and serum samples were frozen and stored until they were analyzed for prolactin levels.The data collected were statistically analyzed

Thesis 2017
-Elembaby-Doha Abdelaty Kamal El Deen
570 علم الحياة   570 علم الحياة  
The electronic spectrum of Pb(II) complexes before and after γ-
irradiation display bands at 340 - 354 nm which may be assigned to n-π*
transitions. The coordination of the acetate ion to the octahedral lead
center is confirmed by its non-electrolytic nature in DMF solution. The
Pb complexes show no d-d band - also the Pb complexes contain only
paired electrons and was found to
تصفح الوعاء  


من 4
 







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