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تصفح المحتوي RDA
التصفح حسب الموضوعات
التصفح حسب اللغة
التصفح حسب الناشر
التصفح حسب تاريخ النشر
التصفح حسب مكان النشر
التصفح حسب المؤلفين
تصفح الهيئات
التصفح المؤتمرات
التصفح حسب نوع المادة
التصفح حسب العلاقة بالعمل
تم العثور علي : 71
 تم العثور علي : 71
  
 
إعادة البحث

Thesis 2023.

Thesis 2020

Thesis 2023.
The goal of the current thesis was to formulate niosomes of acemetacin (ACM) and
mefenamic acid (MEF) and developed them to improve their tumor targeting in
addition to radio-kinetic evaluation performed using 131I. Niosomes were prepared by
ether injection method and characterized for particle size (PS)
- polydispersity index
(PDI)
- zeta potential (ZP) - entrapment efficiency (EE%) and in vitro drug release.
Factors affecting radiolabeling with 131I were studied and optimized. Radio-kinetic
evaluation was done for 131I-ACM optimum niosomal and 131I-MEF optimum niosomal
formula by intravenous (I.V) administration to solid tumor bearing mice and compared
to I.V 131I-ACM solution and I.V 131I-MEF solution as a control
- respectively. The
average droplet size
- zeta potential and in vitro release after 24 h for the optimum ACM
niosomal formula were 315.23 ± 5.37 nm
- − 9.16 ± 2.91 and 76 % - respectively. The
greatest labeling yield of 131I-ACM was 93.1 ± 1.1%. Radio-kinetic evaluation showed
a maximum tumor uptake of 5.431 %ID/g for 131I-ACM niosomal formula and 2.601
%ID/g for 131I-ACM solution at 60 min post I.V. injection. While the average PS and
ZP values for the optimum MEF niosomal formulation were 247.23 ± 2.32 nm and –
28.3 ± 1.21
- respectively. In vitro release study of the optimum formula showed
appropriate cumulative drug release of (77.73 %) after 24 hr. The highest labeling yield
of 131I-MEF was 98.7  0.8%. The biodistribution study revealed that the highest tumor
uptake of 131I-MEF niosomal formula and 131I-MEF solution at 60 min after I.V.
injection were 2.73 and 1.94 % ID/g
- respectively.
As a conclusion
- ACM-loaded niosomes and MEF-loaded niosomes are excellent
substitutes in cancer treatment due to enhanced tumor uptake of 131I-ACM and 131IMEF
by passive targeting of the nanosized niosomes
- which was confirmed by
radiokinetic evaluation
- Pharmaceutics - Nano

Thesis

Thesis 2015.

Thesis 2019
Intrusion Detection Systems (IDSs) - are the most
appropriate methods to prevent and detect the attacks of
networks and computer systems. The security system
development
- in the computing world - still requires
accurate work. Artificial intelligence technique can make
IDSs easier than before. As always
- the most important
thing is to know more about smart systems through training
to acquire the truth things. This thesis focuses on creating
an environment for IDSs to teach them to practice the work
such as a security officer. The study presents several ways
to discover network anomalies using data mining tasks
-
deep learning technology. In this thesis
- two smart hybrid
systems were developed to explore any penetrations inside
the network. The first model divides into two basic stages.
The first stage includes the Genetic Algorithm (GA) in
selecting the characteristics with depends on a process of
extracting
- Discretize And dimensionality reduction
through Proportional k-Interval Discretization (PKID) and
Fisher Linear Discriminant Analysis (FLDA) respectively.
At the end of the first stage combining classifier Naïve
Bayes and Decision Table classifier using NSL-KDD data
divided into two separate groups for training and testing.
The second stage completely depends on the first stage
outputs in order to improve the performance in terms of the
maximum accuracy in classification of penetrations
- raising
the average of discovering and reducing of the average of
false alarms through participation with the Deep Learning
(DL) technology and collaboration with an algorithm
(SGD). The second hybrid model relies upon Particle

Thesis 2022

Thesis 2018.

Thesis 2021 .

Thesis 2021.


من 8
 







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